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Invitrogen™ TRAF2 Monoclonal Antibody (33A1293)
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Catalog No. 01676443
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100 μg
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Catalog No. Quantity
01-676-443 100 μg
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Catalog No. 01-676-443 Supplier Invitrogen™ Supplier No. MA141028
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Description

Mouse Monoclonal Antibody

Suggested positive control: Hela whole cell extract, antigen standard for TRAF2 (transient overexpression lysate).

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRAF2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 33A1293
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene TRAF2
Gene Accession No. Q12933
Gene Alias AI325259; E3 ubiquitin-protein ligase TRAF2; MGC:45012; OTTHUMP00000064745; RING-type E3 ubiquitin transferase TRAF2; TNF receptor associated factor 2; Tnf receptor-associated factor 2; TRAF2; TRAP; TRAP3; tumor necrosis factor type 2 receptor associated protein 3; tumor necrosis factor type 2 receptor-associated protein 3
Gene Symbols TRAF2
Host Species Mouse
Immunogen Fusion protein corresponding to amino acids 205 to 222 of human TRAF2.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7186
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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