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Invitrogen™ TRAF6 Polyclonal Antibody
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Catalog No. 01676630
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100 μg
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Catalog No. Quantity
01-676-630 100 μg
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Catalog No. 01-676-630 Supplier Invitrogen™ Supplier No. PA141008
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Description

Rabbit Polyclonal Antibody

Suggested positive control: human thymus, testis cell lysate, antigen standard for TRAF6 (transient overexpression lysate). Immunogen sequence homology: sooty mangabey (Cercocebus atys) (98%).

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRAF6
Applications Flow Cytometry, Western Blot
Classification Polyclonal
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TRAF6
Gene Accession No. Q9Y4K3
Gene Alias 2310003F17Rik; AI851288; C630032O20Rik; E3 ubiquitin-protein ligase TRAF6; interleukin-1 signal transducer; MGC:3310; RING finger protein 85; RING-type E3 ubiquitin transferase TRAF6; RNF85; TNF receptor associated factor 6; TNF receptor-associated factor 6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase; Traf6
Gene Symbols TRAF6
Host Species Rabbit
Immunogen Peptide corresponding to amino acids between 410 and 460 of human TRAF6.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7189
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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