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Invitrogen™ TRAF7 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA141285
Description
Suggested positive control: antigen standard for TRAF7 (transient overexpression lysate).
TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670 A. A protein, is a human homolog of mouse Traf7 andconsists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways. It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells.
Specifications
TRAF7 | |
Polyclonal | |
Unconjugated | |
TRAF7 | |
DKFZp586I021; E3 ubiquitin-protein ligase TRAF7; MGC7807; RFWD1; RGD1559653; ring finger and WD repeat domain 1; ring finger and WD repeat domain 1 isoform 1; RING finger and WD repeat-containing protein 1; RING finger protein 119; RING-type E3 ubiquitin transferase TRAF7; RNF119; TNF receptor associated factor 7; TNF receptor-associated factor 7; TNF receptor-associated factor 7, E3 ubiquitin protein ligase; traf7 | |
Rabbit | |
Protein G | |
RUO | |
100065698, 224619, 360491, 84231 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunoprecipitation, Western Blot | |
1.0 mg/mL | |
PBS with 0.05% sodium azide | |
Q6Q0C0, Q922B6 | |
TRAF7 | |
Synthetic peptide corresponding to residues 334-356 of humanTRAF7. | |
100 μg | |
Primary | |
Human, Mouse, Rat, Horse | |
Antibody | |
IgG |
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