Invitrogen™ TRAF7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA141285

Catalog No. 01-675-626

Description

Suggested positive control: antigen standard for TRAF7 (transient overexpression lysate).

TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670 A. A protein, is a human homolog of mouse Traf7 andconsists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways. It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells.

Specifications

• Antigen: TRAF7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRAF7
• Gene Alias: DKFZp586I021; E3 ubiquitin-protein ligase TRAF7; MGC7807; RFWD1; RGD1559653; ring finger and WD repeat domain 1; ring finger and WD repeat domain 1 isoform 1; RING finger and WD repeat-containing protein 1; RING finger protein 119; RING-type E3 ubiquitin transferase TRAF7; RNF119; TNF receptor associated factor 7; TNF receptor-associated factor 7; TNF receptor-associated factor 7, E3 ubiquitin protein ligase; traf7
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 100065698, 224619, 360491, 84231
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot
• Concentration: 1.0 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: Q6Q0C0, Q922B6
• Gene Symbols: TRAF7
• Immunogen: Synthetic peptide corresponding to residues 334-356 of humanTRAF7.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Horse
• Product Type: Antibody
• Isotype: IgG