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TRAM 39

Catalog No. 49525
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5 mg
25 mg
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Catalog No. Quantity
49-525 5 mg
49-522-5 25 mg
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Catalog No. 49-525 Supplier R&D Systems Supplier No. 4952/5
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Description

Potent KCa3.1 (IK) blocker

TRAM 39 is a potent intermediate conductance Ca2+-activated K+ channel (KCa3.1) blocker (Kd = 60 nM). Has no effect on cytochrome p450 activity. Inhibits I-EBIO -stimulated increases in rat artery membrane potential ex vivo. Also diminishes LPS-induced cryptidin (mammalian α-defensin) release from paneth cells in vitro.

Specifications

Chemical Name or Material 2-Chloro-α,α-diphenylbenzeneacetonitrile
CAS 197525-99-8
Assay Percent Range >99%
Quantity 5 mg
Molecular Formula C20H14ClN
Formula Weight Observed MW: 303.78
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