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  5. Tocris Bioscience™ Trametinib

Tocris Bioscience™ Trametinib
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Catalog No. 770950
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77-095-0 50 mg
77-091-0 10 mg
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Catalog No. 77-095-0 Supplier Tocris Bioscience™ Supplier No. 7709/50
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Description

Potent and selective MEK inhibitor; orally bioavailable

Trametinib is a potent and selective MEK1 and MEK2 inhibitor (IC50 = 0.92 and 1.8 nM, respectively, in cell-free assays). In vitro, it inhibits the growth of human colorectal cancer cell lines expressing either B-RAF or K-RAF (IC50 values range from 0.48 to 36 nM). In vivo, it suppresses tumor growth of HT-29 and COLO205 xenografts in nude mice. Trametinib induces apoptosis. This compound is orally bioavailable.

Specifications

Chemical Name or Material N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2 H)-yl]phenyl]acetamide
CAS 871700-17-3
Quantity 50 mg
Target MEK Inhibitors
Molecular Formula C26H23FIN5O4
Purity 0.98
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