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Invitrogen™ Transferrin Receptor Monoclonal Antibody (MEM-75), Alexa Fluor™ 647
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Catalog No. PIMA518151
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100 Tests
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PIMA518151 100 Tests
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Catalog No. PIMA518151 Supplier Invitrogen™ Supplier No. MA518151
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Description

Mouse Monoclonal Antibody

This antibody reacts with an extracellular epitope of CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes. The antibody MEM-75 does not block binding of transferrin to the receptor.

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Transferrin Receptor
Applications Flow Cytometry, Immunocytochemistry
Classification Monoclonal
Clone MEM-75
Concentration 0.16 mg/mL
Conjugate Alexa Fluor 647
Formulation PBS with 0.2% BSA and 15mM sodium azide
Gene TFRC
Gene Accession No. P02786
Gene Alias 2610028K12Rik; AI195355; AI426448; AU015758; CD antigen CD71; CD71; chicken transferrin receptor; E430033M20Rik; I79_000642; IMD46; mammary tumor virus receptor 1; Mtvr1; Mtvr-1; p90; sTfR; T9; TfR; tfR1; TFR2; TFRC; TR; transferrin receptor; transferrin receptor (p90, CD71); transferrin receptor 2; transferrin receptor protein 1; Transferrin receptor protein 1, serum form; Trfr
Gene Symbols TFRC
Host Species Mouse
Immunogen NALM-6 human pre-B cell line.
Purification Method Size-exclusion chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7037
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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