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Invitrogen™ Transferrin Receptor Monoclonal Antibody (MEM-75), Biotin

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA119505

Catalog No. 01-676-239


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Description

Description

This antibody reacts with an extracellular epitope of CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes. The antibody MEM-75 does not block binding of transferrin to the receptor.

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Transferrin Receptor
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
P02786
TFRC
Pre-B cell line NALM-6.
100 μg
Primary
Human
Antibody
IgG1
Flow Cytometry, Immunoprecipitation, Immunocytochemistry
MEM-75
Biotin
TFRC
2610028K12Rik; AI195355; AI426448; AU015758; CD antigen CD71; CD71; chicken transferrin receptor; E430033M20Rik; I79_000642; IMD46; mammary tumor virus receptor 1; Mtvr1; Mtvr-1; p90; sTfR; T9; TfR; tfR1; TFR2; TFRC; TR; transferrin receptor; transferrin receptor (p90, CD71); transferrin receptor 2; transferrin receptor protein 1; Transferrin receptor protein 1, serum form; Trfr
Mouse
Size-exclusion Chromatography
RUO
7037
4°C, do not freeze
Liquid
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