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Invitrogen™ Transferrin Receptor Monoclonal Antibody (MEM-75), Biotin
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA119505
Description
This antibody reacts with an extracellular epitope of CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes. The antibody MEM-75 does not block binding of transferrin to the receptor.
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
Specifications
Transferrin Receptor | |
Monoclonal | |
1 mg/mL | |
PBS with 15mM sodium azide; pH 7.4 | |
P02786 | |
TFRC | |
Pre-B cell line NALM-6. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
Flow Cytometry, Immunoprecipitation, Immunocytochemistry | |
MEM-75 | |
Biotin | |
TFRC | |
2610028K12Rik; AI195355; AI426448; AU015758; CD antigen CD71; CD71; chicken transferrin receptor; E430033M20Rik; I79_000642; IMD46; mammary tumor virus receptor 1; Mtvr1; Mtvr-1; p90; sTfR; T9; TfR; tfR1; TFR2; TFRC; TR; transferrin receptor; transferrin receptor (p90, CD71); transferrin receptor 2; transferrin receptor protein 1; Transferrin receptor protein 1, serum form; Trfr | |
Mouse | |
Size-exclusion Chromatography | |
RUO | |
7037 | |
4°C, do not freeze | |
Liquid |
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