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Invitrogen™ Trastuzumab Chimeric Recombinant Rabbit Monoclonal Antibody (4D5-8 (trastuzumab))
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Catalog No. PIMA547755
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200 μg
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PIMA547755 200 μg
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Catalog No. PIMA547755 Supplier Invitrogen™ Supplier No. MA547755
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30% of invasive breast cancers and 70% of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder.

Trastuzumab with the brand name Herceptin, is an FDA-approved drug for HER2-targeted therapy for breast cancer. It is a recombinant humanized monoclonal antibody (IgG1 kappa). Trastuzumab binds to HER2 receptor present on the surface of HER2-positive tumour cells and suppresses the cells growth and proliferation.
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Specifications

Antigen Trastuzumab Chimeric
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin)
Classification Recombinant Monoclonal
Clone 4D5-8 (trastuzumab)
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene Alias Herceptin
Host Species Rabbit
Immunogen A431 cells (human epidermoid carcinoma) (over)expressing EGFR.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
Target Molecule Chemical
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