TREM-1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA587413

Catalog No. PIPA587413

Description

Positive Samples: HL-60; Cellular Location: Cell membrane, Single-pass type I membrane protein Immunogen sequence: ATKLTEEKYE LKEGQTLDVK CDYTLEKFAS SQKAWQIIRD GEMPKTLACT ERPSKNSHPV QVGRIILEDY HDHGLLRVRM VNLQVEDSGL YQCVIYQPPK EPHMLFDRIR LVVTKGFSGT PGSNENSTQN VYKIPPTTTK ALCPLYTSPR TVTQAPPKST ADVSTPDSEI NLTNVTDIIR VPVFN

TREM1 (triggering receptor expressed on myeloid cells 1) is a receptor belonging to the Ig superfamily that amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. It is thought that TREM1 other related TREM proteins such as TREM2 act to modulate the inflammatory response. TREM1 has also been linked to inflammatory bowel disease resulting in enhanced production of TNF, IL-6, IL-8, and MCP-1.

Specifications

• Antigen: TREM-1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TREM1
• Gene Alias: CD354, sCD354, soluble CD354, soluble TREM 1, soluble TREM1, sTREM 1, sTREM1, TREM, Trem1, TREM-1, triggering receptor expressed in monocytes 1, triggering receptor expressed on monocytes 1, Triggering receptor expressed on myeloid cells, Triggering receptor expressed on myeloid cells 1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54210
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 5.89 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
• Gene Accession No.: Q9NP99
• Gene Symbols: TREM1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 21-205 of human TREM1 (NP_0611131)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG