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Invitrogen™ TREM1 Monoclonal Antibody (L5-B8.2A12.3A12)
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Catalog No. PIMA516765
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500 μg
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PIMA516765 500 μg
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Catalog No. PIMA516765 Supplier Invitrogen™ Supplier No. MA516765
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Description

Rat Monoclonal Antibody

The epitope recognized by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. We recommend the use of acetone fixation for frozen sections. For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. This product is a low-endotoxin, preservative-free formulation. Endotoxin level is <0.01EU/ug. Rat anti Mouse Trem-1 antibody, clone L5-B8.2A12.3A12 recognizes mouse triggering receptor expressed on myeloid cells 1 (TREM-1), a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes.

TREM1 (triggering receptor expressed on myeloid cells 1) is a receptor belonging to the Ig superfamily that amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. It is thought that TREM1 other related TREM proteins such as TREM2 act to modulate the inflammatory response. TREM1 has also been linked to inflammatory bowel disease resulting in enhanced production of TNF, IL-6, IL-8, and MCP-1.
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Specifications

Antigen TREM1
Applications Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone L5-B8.2A12.3A12
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene TREM1
Gene Accession No. Q9JKE2
Gene Alias CD354; sCD354; soluble CD354; soluble TREM 1; soluble TREM1; sTREM 1; sTREM1; TREM; Trem1; TREM-1; triggering receptor expressed in monocytes 1; triggering receptor expressed on monocytes 1; Triggering receptor expressed on myeloid cells; Triggering receptor expressed on myeloid cells 1
Gene Symbols TREM1
Host Species Rat
Immunogen Mouse TREM-1 Fc fusion protein.
Purification Method Protein G
Quantity 500 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 58217
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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