Invitrogen™ TREM1 Monoclonal Antibody (L5-B8.2A12.3A12)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA516765

Catalog No. PIMA516765

Description

The epitope recognized by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. We recommend the use of acetone fixation for frozen sections. For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. This product is a low-endotoxin, preservative-free formulation. Endotoxin level is <0.01EU/ug. Rat anti Mouse Trem-1 antibody, clone L5-B8.2A12.3A12 recognizes mouse triggering receptor expressed on myeloid cells 1 (TREM-1), a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes.

TREM1 (triggering receptor expressed on myeloid cells 1) is a receptor belonging to the Ig superfamily that amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. It is thought that TREM1 other related TREM proteins such as TREM2 act to modulate the inflammatory response. TREM1 has also been linked to inflammatory bowel disease resulting in enhanced production of TNF, IL-6, IL-8, and MCP-1.

Specifications

• Antigen: TREM1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q9JKE2
• Gene Symbols: TREM1
• Immunogen: Mouse TREM-1 Fc fusion protein.
• Quantity: 500 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Clone: L5-B8.2A12.3A12
• Conjugate: Unconjugated
• Gene: TREM1
• Gene Alias: CD354; sCD354; soluble CD354; soluble TREM 1; soluble TREM1; sTREM 1; sTREM1; TREM; Trem1; TREM-1; triggering receptor expressed in monocytes 1; triggering receptor expressed on monocytes 1; Triggering receptor expressed on myeloid cells; Triggering receptor expressed on myeloid cells 1
• Host Species: Rat
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 58217
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid