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Invitrogen™ TREX2 Polyclonal Antibody
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Catalog No. PIPA595388
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100 μg
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PIPA595388 100 μg
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Catalog No. PIPA595388 Supplier Invitrogen™ Supplier No. PA595388
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Description

Rabbit Polyclonal Antibody

Human TREX2 shares 88.6% amino acid (aa) sequence identity with mouse TREX2. Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: HELA whole cell, MCF-7 whole cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

TREX2 is one of two major human 3' to 5' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TREX2
Applications Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 5mg BSA and 0.05mg sodium azide
Gene TREX2
Gene Accession No. Q9BQ50
Gene Alias 3'-5' exonuclease TREX2; 3'-5' exonuclease TREX2 long form; RGD1562245; Three prime repair exonuclease 2; Trex2
Gene Symbols TREX2
Host Species Rabbit
Immunogen E.coli-derived human TREX2 recombinant protein (Position: E69-A279).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11219
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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