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Invitrogen™ TRF2 Polyclonal Antibody
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Catalog No. 01676637
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100 μg
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Catalog No. Quantity
01-676-637 100 μg
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Catalog No. 01-676-637 Supplier Invitrogen™ Supplier No. PA141023
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Description

Goat Polyclonal Antibody

Suggested positive control: antigen standard for TERF2 (transient overexpression lysate), Daudi, HeLa, HL-60, or Jurkat. Immunogen sequence homology: rat (86%).

TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRF2
Applications ChIP Assay, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene TERF2
Gene Accession No. Q15554
Gene Alias Telomeric DNA-binding protein; telomeric repeat binding factor 2; telomeric repeat binding protein 2; telomeric repeat-binding factor 2; TERF2; TRBF2; TRF2; TTAGGG repeat-binding factor 2
Gene Symbols TERF2
Host Species Goat
Immunogen Baculovirus expressed His-tagged whole length TRF-2 protein.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7014
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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