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TRIAD3 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501988859
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50-198-8859 100 μL
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Catalog No. 50-198-8859 Supplier Bioss Supplier No. BS9154R
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Description

Rabbit Polyclonal Antibody

Activation of NF-κB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88. Several regulatory mechanisms exist to control TLR signal transduction, including the inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR. Another mechanism is by the ubi-quitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase. TRIAD3A is a RING finger protein that can bind to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing the ubiquitization of these molecules. Overexpression of TRIAD3A promoted the nearly complete degradation of TLR4 and TLR9; this reduction was reflected in the decreased signal-specific activation by ligands specific for these TLRs. Conversely, depletion of TRIAD3A resulted in enhanced TLR activation.

Specifications

Antigen TRIAD3
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene RNF216
Gene Accession No. Q9NWF9
Gene Alias 2810055G22Rik; AI647468; AU019462; C86502; CAHH; E3 ubiquitin ligase; E3 ubiquitin-protein ligase RNF216; F830018F18Rik; RING finger protein 216; RING-type E3 ubiquitin transferase RNF216; RNF216; Triad domain-containing protein 3; Triad3; U7I1; UBCE7IP1; UbcM4-interacting protein 83; Ubiquitin-conjugating enzyme 7-interacting protein 1; Uip83; ZIN; Zinc finger protein inhibiting NF-kappa-B
Gene Symbols RNF216
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human TRIAD3.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54476
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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