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Invitrogen™ Triadin Monoclonal Antibody (GE 4.90)
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Catalog No. MA3927
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200 μL
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MA3927 200 μL
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Catalog No. MA3927 Supplier Invitrogen™ Supplier No. MA3927
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Description

Mouse Monoclonal Antibody

MA3-927 detects triadin from mouse, rabbit and rat tissues. MA3-927 has been successfully used in Western blot, immunohistochemistry, immunoprecipitation and ELISA procedures. By Western blot, this antibody detects a 95 kDa protein representing triadin from rabbit skeletal muscle extracts. Immunohistochemical staining of triadin in rat skeletal muscle with MA3-927 results in striated staining consistent with sarcoplasmic reticulum localization. The MA3-927 antigen is purified rabbit fast skeletal muscle triadin.

The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad. At the triad, dihydropyridine receptors (DHPR's) of the T-tubule serve as voltage sensors in excitation-contraction coupling, while ryanodine receptors (RyR's), the calcium release channels, exist in the membrane of the terminal cisternae of the SR. It is thought that during slow phase depolarization of the T-tubule, a third protein, triadin (MW 95 kDa) transmits electrochemical signals to the SR through direct interaction with both DHPR's and RyR's. Though its exact role in this signaling process is unclear, triadin has been shown to co-localize with both DHPR and RYR at the junctional face of the terminal cisternae.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Triadin
Applications ELISA, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone GE 4.90
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.05% sodium azide
Gene TRDN
Gene Accession No. E9Q9K5, Q28820, Q9QX75
Gene Alias 2310045H21Rik; cardiac triadin; cardiac triadin isoform 1; cardiac triadin isoform 2; cardiac triadin isoform 3; CPVT5; EG432451; junctional sarcoplasmic reticulum glycoprotein; TDN; Trdn; Triadin; triadin 1; triadin 32 kDa (TRISK 32); triadin 49 kDa (TRISK 49); triadin 95; TRISK
Gene Symbols TRDN
Host Species Mouse
Immunogen Purified rabbit fast skeletal muscle triadin.
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100009519, 59299, 76757
Target Species Mouse, Rabbit, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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