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Invitrogen™ TRIM72 Monoclonal Antibody (A1D4)
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Catalog No. PIMA534958
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100 μL
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PIMA534958 100 μL
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Catalog No. PIMA534958 Supplier Invitrogen™ Supplier No. MA534958
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Description

Mouse Monoclonal Antibody

Positive Control: HCT116 cell lysates, rat skeletal muscle tissue, human pancreas tissue, A549.

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TRIM72
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone A1D4
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.2% BSA and 0.05% sodium azide; pH 7.4
Gene TRIM72
Gene Accession No. Q6ZMU5
Gene Alias BC067209; mg53; mitsugumin 53; mitsugumin-53; RGD1562778; TRIM72; trim72 {ECO:0000250; tripartite motif containing 72; tripartite motif containing 72, E3 ubiquitin protein ligase; tripartite motif-containing 72; tripartite motif-containing protein 72; UniProtKB:Q8N4X6}
Gene Symbols TRIM72
Host Species Mouse
Immunogen Recombinant protein with Human TRIM72 aa 50-150.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 493829
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1
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