Invitrogen™ TRIM72 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA519398

Catalog No. PIPA519398

Description

This antibody is predicted to react with bovine and canine based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.

Specifications

• Antigen: TRIM72
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TRIM72
• Gene Alias: BC067209; mg53; mitsugumin 53; mitsugumin-53; RGD1562778; TRIM72; trim72 {ECO:0000250; tripartite motif containing 72; tripartite motif containing 72, E3 ubiquitin protein ligase; tripartite motif-containing 72; tripartite motif-containing protein 72; UniProtKB:Q8N4X6}
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 434246, 493829
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q1XH17, Q6ZMU5
• Gene Symbols: TRIM72
• Immunogen: Synthetic peptide sequence (RPQALSTNLQ) corresponding to the internal amino acids of TRIM72 (aa 61-70).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG