Trimethyl orthoformate, 99%

Description

CAS: 149-73-5 | C4H10O3 | 106.121 g/mol

Trimethyl orthoformate is used as a protecting group for aldehydes in organic synthesis, as an additive in polyurethane coatings and as a dehydrating agent in the preparation of surface modified colloidal silica nanoparticles. It is also used as a chemical intermediate in the preparation of vitamin B1 and sulfa drugs. It acts as an effective solvent for thallium(III) nitrate-mediated oxidations. Furthermore. It is utilized for the synthesis of chromone from keto-hydroxy naphthol in the presence of trimethylamine.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Trimethyl orthoformate is used as a protecting group for aldehydes in organic synthesis, as an additive in polyurethane coatings and as a dehydrating agent in the preparation of surface modified colloidal silica nanoparticles. It is also used as a chemical intermediate in the preparation of vitamin B1 and sulfa drugs. It acts as an effective solvent for thallium(III) nitrate-mediated oxidations. Furthermore. It is utilized for the synthesis of chromone from keto-hydroxy naphthol in the presence of trimethylamine.

Solubility
Miscible with ether, alcohol and benzene.

Notes
Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with acids and strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 149-73-5
• Molecular Formula: C4H10O3
• Molecular Weight (g/mol): 106.121
• MDL Number: MFCD00008483
• InChI Key: PYOKUURKVVELLB-UHFFFAOYSA-N
• Synonym: trimethyl orthoformate, methyl orthoformate, methane, trimethoxy, orthoformic acid, trimethyl ester, orthoformic acid methyl ester, orthomravencan methylnaty, methoxymethylal, methylester kyseliny orthomravenci, unii-xam28819yj, orthoformic acid trimethyl ester
• PubChem CID: 9005
• IUPAC Name: trimethoxymethane
• SMILES: COC(OC)OC

• Melting Point: -53°C
• Density: 0.968
• Boiling Point: 101°C to 102°C
• Flash Point: 15°C (59°F)
• Refractive Index: 1.379
• Quantity: 100 mL
• UN Number: UN3272
• Beilstein: 969215
• Sensitivity: Moisture sensitive
• Merck Index: 14,6884
• Solubility Information: Miscible with ether,alcohol and benzene.
• Formula Weight: 106.12
• Percent Purity: 99%
• Chemical Name or Material: Trimethyl orthoformate

Safety and Handling

Hazard Category	H225-H319-H335
Hazard Statement	GHS H Statement H225-H315-H319-H335 Highly flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P210-P233-P235-P240-P241-P242-P243-P261-P264b-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P370+P378q-P501c
DOTInformation	Transport Hazard Class: 3; Packing Group: II; Proper Shipping Name: ESTERS, N.O.S.
EINECSNumber	205-745-7
RTECSNumber	RM6650000
TSCA	Yes
Recommended Storage	Ambient temperatures; Store under Nitrogen

SDS

RUO – Research Use Only