Trimethyl phosphonoacetate, 98%

Description

CAS: 5927-18-4 | C5H11O5P | 182.112 g/mol

Trimethyl phosphonoacetate is used in the preparation of sarin A by intramolecular Mannich-type reactions. It is involved in the Horner-Wadsworth-Emmons olefination with aldehydes and ketones to give acrylic esters. It is also involved in oxa-Michael reactions, prenylation of oxindoles and heterocyclization reactions.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Trimethyl phosphonoacetate is used in the preparation of sarin A by intramolecular Mannich-type reactions. It is involved in the Horner-Wadsworth-Emmons olefination with aldehydes and ketones to give acrylic esters. It is also involved in oxa-Michael reactions, prenylation of oxindoles and heterocyclization reactions.

Solubility
Slightly miscible with water.

Notes
Incompatible with strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 5927-18-4
• Molecular Formula: C5H11O5P
• Molecular Weight (g/mol): 182.112
• MDL Number: MFCD00008452
• InChI Key: SIGOIUCRXKUEIG-UHFFFAOYSA-N
• Synonym: trimethyl phosphonoacetate, methyl 2-dimethoxyphosphoryl acetate, trimethyl phosphonacetate, trimethylacetyl phosphate, acetic acid, dimethoxyphosphinyl-, methyl ester, methyl-dimethoxyphosphoryl acetat, trimethyl phosphoroacetate, phosphonoacetic acid trimethyl ester, methyl dimethylphosphonoacetate, methyl dimethoxyphosphoryl acetate
• PubChem CID: 80029
• IUPAC Name: methyl 2-dimethoxyphosphorylacetate
• SMILES: COC(=O)CP(=O)(OC)OC

• Density: 1.263
• Boiling Point: 119°C to 120°C (1 mmHg)
• Flash Point: 70°C (158°F)
• Refractive Index: 1.437
• Quantity: 25 g
• Beilstein: 1865177
• Solubility Information: Slightly miscible with water.
• Formula Weight: 182.11
• Percent Purity: 98%
• Chemical Name or Material: Trimethyl phosphonoacetate

Safety and Handling

Hazard Category	Warning
Hazard Statement	GHS H Statement H315-H319-H335-H227 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.
Precautionary Statement	GHS P Statement P210-P261-P280-P305+P351+P338-P405-P501a Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapors/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.
EINECSNumber	227-663-0
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only