Trimethylacetyl chloride, 98+%, Thermo Scientific Chemicals

Description

Trimethylacetyl chloride is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria. It is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament. In addition to this, it is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine. It is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Trimethylacetyl chloride is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria. It is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament. In addition to this, it is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine. It is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides.

Solubility
Miscible with acetonitrile.

Notes
Moisture sensitive. Incompatible withalcohols, oxidizing agents and strong bases.

Specifications

Chemical Identifiers

• CAS: 3282-30-2
• Molecular Formula: C5H9ClO
• Molecular Weight (g/mol): 120.58
• MDL Number: MFCD00000709
• InChI Key: JVSFQJZRHXAUGT-UHFFFAOYSA-N
• Synonym: pivaloyl chloride, trimethylacetyl chloride, propanoyl chloride, 2,2-dimethyl, pivalyl chloride, pivaloylchloride, 2,2-dimethylpropionyl chloride, pivalic acid chloride, pivalolyl chloride, unii-jq82j0o21t, 2,2-dimethylpropionylchloride
• PubChem CID: 62493
• IUPAC Name: 2,2-dimethylpropanoyl chloride
• SMILES: CC(C)(C)C(Cl)=O

• Melting Point: -57°C
• Density: 0.985
• Boiling Point: 105°C to 106°C
• Flash Point: 8°C (46°F)
• Odor: Pungent
• Refractive Index: 1.412
• Quantity: 100 mL
• UN Number: UN2438
• Beilstein: 385668
• Sensitivity: Moisture sensitive
• Solubility Information: Miscible with acetonitrile.
• Formula Weight: 120.58
• Percent Purity: ≥98%
• Chemical Name or Material: Trimethylacetyl chloride

Safety and Handling

Hazard Category	H225-H290-H302-H314-H330
Hazard Statement	GHS H Statement H225-H330-H314-H318-H302 Highly flammable liquid and vapour. Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. Harmful if swallowed.
Precautionary Statement	P210-P233-P234-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P280-P284-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P370+P378q-P390-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: I; Proper Shipping Name: TRIMETHYLACETYL CHLORIDE
EINECSNumber	221-921-6
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only