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Cayman Chemical THUNDREXreme PhosphoRK1 4800
SDP

Supplier:  Cayman Chemical 5002914800 WELL

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An ALK5 inhibitor (IC50 0.0015 UM) selective for ALK over TGF-BRII (IC50 > 15 UM) and a panel of 213 additional kinases at 1 UM inhibits TGF-B-induced increases in the nuclear translocation of phosphorylated SMAD2/3 in Mv 1 Lu cells (IC50 0.35 UM) decreases tumor growth in an MC-38 murine colon carcinoma model of tumor rechallenge at 3.75 mg/kg per day in combination with an antibody against PD-1 induces hyperproliferation of chondrocytes in the femoral epiphysis thickening of the cardiac atrioventricular valve and inflammation in the aortic vasculature in rats at 10 mg/kg per day

Catalog No. 50-289-4261


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