TrkB Rabbit anti-Human, Mouse, Porcine, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-8511	Proteintech Group Inc 131291AP150UL	150 μL

Description

TrkB is a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). TrkB is involved in the development and maintece of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.

Specifications

• Antigen: TrkB
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Pig, Rat
• Gene Accession No.: P15209, Q16620, Q63604
• Gene ID (Entrez): 100519209, 18212, 25054, 4915
• Immunogen: TrkB Fusion Protein Ag3790
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: NTRK2

• Concentration: 0.27 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: GP145 TrkB, NTRK2, TrkB, TrkB tyrosine kinase
• Gene Symbols: Ntrk2
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody