TRMT12 Monoclonal Antibody (OTI1C9), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA809532

Catalog No. 50-168-2861

Description

TYW2, also known as TRM12, is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW2 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW2 was found to be amplified in 7 of 8 breast cancers cell lines analyzed, and qPCR analysis of 30 breast tumors showed overexpression of TYW2 mRNA of over 2-fold in 26, suggesting that TYW2 may play a role in breast cancer.

Specifications

• Antigen: TRMT12
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q53H54
• Gene Symbols: TRMT12
• Immunogen: Full length human recombit protein of human TRMT12 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1C9
• Conjugate: Unconjugated
• Gene: TRMT12
• Gene Alias: TRM12, TYW2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55039
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid