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Cayman Chemical Troglitazone, 97322-87-7, 5 mg
SDP

Supplier:  Cayman Chemical 717505

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Molecular Formula C24H27NO5S, Purity ≥98%, Formula Weight 441.5, Synonyms: Resulin™; Troglitazone is a TZD which was approved for the treatment of insulin resistance and hyperglycemia in Type II diabetes, under the trade name Resulin™, but was withdrawn from the market due to hepatotoxicity. Troglitazone is a potent and selective PPAR agonist. The EC50 values for transactivation of human and mouse PPAR in a cell-based assay are 0.55 and 0.78 M, respectively.{10670} In the same assay system, no activation of PPAR and PPAR.delta. was observed at concentrations up to 10 M. Troglitazone binds to the PPAR ligand-binding domain (LBD) but fails to induce interaction of the PPAR LBD with the transcriptional coactivators SRC-1, TIF2, AIB1, p300, or TRAP220.{8555} Troglitazone also induces cell cycle arrest and apoptosis in several cancer cell lines with an EC50 of 10 M.{10669}

Catalog No. NC9902151


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