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Trop2 (EGP-1) Monoclonal Antibody (MR54), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  LIFE TECHNOLOGIES 14602482

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Catalog No. 50-245-570


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Description

Description

Description: This MR54 monoclonal antibody reacts with human Trop-2, which is also known as Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) and EGP-1. This type I transmembrane glycoprotein is expressed on trophoblast (syncytiotrophoblast and cytotrophoblast), epithelial, and most human carcinoma cells. Trop-2 plays a role in calcium-mediated signaling. Trop-2 has also been reported as an oncogene, with expression being correlated with tumorigenesis, metastasis, and anchorage-independent growth. Applications Reported: This MR54 antibody has been reported for use in flow cytometric analysis, immunoprecipitation, western blotting, immunohistochemical staining of formalin-fixed paraffin embedded (FFPE) tissue sections (IHC-P), ELISA, and immunocytochemistry (ICC). Applications Tested: This MR54 antibody has been tested by flow cytometry and immunocytochemistry on MCF7 cells as well as by immunohistochemistry of formalin-fixed paraffin embedded tissue using either low or high pH antigen retrieval methods. Use of high pH antigen retrieval results in better staining intensity. This can be used at less than of equal to 5 μg/mL. Is is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

TROP2 is a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of its gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
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Specifications

Specifications

Trop2 (EGP-1)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P09758
TACSTD2
Affinity chromatography
RUO
4070
4°C
Liquid
ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
MR54
Unconjugated
TACSTD2
40kD glycoprotein, identified by monoclonal antibody GA733; C80403; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; EGP1; EGP-1; epithelial glycoprotein-1; GA733; GA7331; GA733-1; gastrointestinal tumor-associated antigen GA7331; GP50; Ly97; lymphocyte antigen 97; M1S1; Membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; parturition-related protein 1; Prp1; TACD2; TACSTD2; Trop2; truncated TACSTD2; tumor-associated calcium signal transducer 2; tunor-associated calcium signal transducer 2
Mouse
100 μg
Primary
Human
Antibody
IgG2a κ
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