Invitrogen™ Troponin I Recombinant Rabbit Monoclonal Antibody (1H11L19)

Catalog No.	Quantity
70-158-5	100 μg

Catalog No. 70-158-5 Supplier Invitrogen™ Supplier No. 701585

Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.

Specifications

• Antigen: Troponin I
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: 1H11L19
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide
• Gene: TNNI1
• Gene Accession No.: P13413, P19237, P19429, P23693, P48787, Q9WUZ5
• Gene Alias: 2700018B22Rik; AI747285; Cardiac troponin I; cardiomyopathy, dilated 2A (autosomal recessive); CMD1FF; CMD2A; CMH7; cTNI; DKFZp451O223; fast skeletal TnI; fsTnI; RCM1; slow skeletal TnI; slow skeletal troponin I isoform; ssTnI; Tn1; TnI; TNN1; TNNC1; TNNI1; TNNI3; Tpn1; troponin 1, type 3; troponin I type 1 (skeletal, slow); troponin I type 3 (cardiac); troponin I, cardiac 3; troponin I, cardiac muscle; troponin I, skeletal, slow; troponin I, skeletal, slow 1; Troponin I, slow isoform; troponin I, slow skeletal; troponin I, slow skeletal muscle; Troponin I, slow-twitch isoform; troponin I1, slow skeletal type; troponin I3, cardiac type
• Gene Symbols: TNNI1, TNNI3
• Host Species: Rabbit
• Immunogen: human Troponin I.
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 21952, 21954, 29248, 29388, 7135, 7137
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov