Invitrogen™ TRPV1 Polyclonal Antibody

Catalog No.	Quantity
01-670-602	100 μL

Catalog No. 01-670-602 Supplier Invitrogen™ Supplier No. PA118350

Description

Rabbit Polyclonal Antibody

Reconstitute in 100 μL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent.

TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. TRPV1 is permeable to calcium, magnesium, and monovalent cations of sodium and potassium. Structurally, TRPV1 contains 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. TRPV1 seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. The expression of TRPV1 appears to be limited to neurons within the sensory ganglia. Four transcript variants encoding TRPV1 with variations in th 5' UTR sequence have been described. Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.

Specifications

• Antigen: TRPV1
• Applications: Immunohistochemistry (Frozen)
• Classification: Polyclonal
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: Whole serum with no preservative
• Gene: TRPV1
• Gene Accession No.: O35433, Q8NER1
• Gene Alias: Capsaicin receptor; cation channel; DKFZp434K0220; non-selective cation channel; osm-9-like TRP channel 1; OTRPC1; si:dkey-9e15.2; transient receptor potential cation channel subfamily V member 1; transient receptor potential cation channel V1; transient receptor potential cation channel, subfamily V, member 1; transient receptor potential V1; transient receptor potential V1 channel; transient receptor potential vanilloid 1 supraoptic nucleus; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; TRPV1; TRPV1/2; TRPV1_SON; TRPV1alpha; TRPV1beta; Vanilloid receptor; vanilloid receptor 1; vanilloid receptor subtype 1; vanilloid receptor type 1 like protein 1; Vanilloid receptor type 1-like; vanilloid type 1 receptor; VR.5'sv; Vr1; VR-1; Vr1l; Vr1l1
• Gene Symbols: TRPV1
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to residues C-Y(531) F S H L K E Y V A S(541) of human capsaicin receptor.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7442, 83810
• Target Species: Human, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG