Invitrogen™ TRPV2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA118351

Catalog No. 01-670-603

Description

Reconstitute in 50 μL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent.

VLR-1 is a calcium-permeable, non-selective cation channel with an outward rectification, that seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. VRL-1 does not respond to capsaicin, acid, or moderate heat, but instead is activated by high temperatures, with a threshold of approximately 52 degrees C. Within sensory ganglia, VRL-1 is most prominently expressed by a subset of medium- to large-diameter neurons, making it a candidate receptor for transducing high-threshold heat responses in this class of cells. VRL-1 transcripts are not restricted to the sensory nervous system, indicating that this channel may be activated by stimuli other than heat. VRL-1 is one of the six members of the vanilloid-like TRP-channel family which is now known as TRPV family.

Specifications

• Antigen: TRPV2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Trpv2
• Gene Alias: GRC; growth factor regulated channel; growth factor-regulated calcium channel; Osm-9-like TRP channel 2; OTRPC2; RP23-234K24.7; Sac2b; Stretch-activated channel 2B; transient receptor potential cation channel subfamily V member 2; transient receptor potential cation channel, subfamily V, member 2; Trpv2; Vanilloid receptor-like protein 1; VRL; Vrl1; VRL-1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29465, 51393
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q9WUD2, Q9Y5S1
• Gene Symbols: Trpv2
• Immunogen: Synthetic peptide corresponding to residues C-K(744) N S A S E E D H L P L Q V L Q S P(761) of rat VRL-1.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG