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TRRAP Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501559336
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50-155-9336 100 μL
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Catalog No. 50-155-9336 Supplier Bethyl Laboratories, Inc Supplier No. A301131A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Specifications

Antigen TRRAP
Applications Immunoprecipitation
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene TRRAP
Gene Accession No. Q9Y4A5
Gene Alias 350/400 kDa PCAF-associated factor; OTTHUMP00000197294; OTTHUMP00000197295; tra1 homolog
Gene Symbols TRRAP
Host Species Rabbit
Immunogen Between 3275 and 3325
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8295
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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