TSEN15 Monoclonal Antibody (OTI5A3), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA812717

Catalog No. 50-168-4660

Description

Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5′ and 3′ splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2′,3′ cyclic phosphate and 5′-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3′-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3′-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.

Specifications

• Antigen: TSEN15
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q8WW01
• Gene Symbols: TSEN15
• Immunogen: Full length human recombit protein of human TSEN15 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI5A3
• Conjugate: Unconjugated
• Gene: TSEN15
• Gene Alias: C1orf19, PCH2F, sen15
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116461, 289083
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid