Invitrogen™ TSH Receptor Monoclonal Antibody (49)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA3218

Catalog No. MA3218

Description

MA3-218 detects both glycosylated and nonglycosylated thyroid stimulating hormone receptor (TSHR) from porcine tissues as well as recombinant human TSHR. MA3-218 has been successfully used in Western blot, immunofluorescence, and ELISA procedures. By Western blot, this antibody detects a 50 kDa and a 63 kDa protein representing unglycosylated and glycosylated TSHR respectively, in transfected Sf9 cell extract. By ELISA MA3-218 has been used in TSH competitive inhibition studies. The MA3-218 antigen is purified extracellular domain of recombinant human thyrotropin receptor. This antibody recognizes an epitope between amino acid residues 277-296 of human TSHR.

TSH Receptor gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: TSH Receptor
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.05% sodium azide
• Gene Accession No.: P16473, Q8SPP9
• Gene Symbols: TSHR
• Immunogen: Purified extracellular domain of recombinant human thyrotropin receptor.
• Regulatory Status: RUO
• Gene ID (Entrez): 397560, 7253
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Clone: 49
• Conjugate: Unconjugated
• Gene: TSHR
• Gene Alias: AI481368; CHNG1; hTSHR-I; hypothroid; hyt; LGR3; MGC141920; pet; seven transmembrane helix receptor; thyroid stimulating hormone receptor; thyroid stimulating hormone receptor, isoform 2; thyroid-stimulating hormone receptor; thyroid-stimulating hormone receptor variant; thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; TSHR; TSH-R; TSHR; seven transmembrane domain G protein-coupled receptor; TSHRA
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Pig
• Product Type: Antibody
• Isotype: IgG1

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov