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Invitrogen™ TSH Receptor Monoclonal Antibody (49)
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Catalog No. MA3218
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100 μL
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MA3218 100 μL
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Catalog No. MA3218 Supplier Invitrogen™ Supplier No. MA3218
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Description

Mouse Monoclonal Antibody

MA3-218 detects both glycosylated and nonglycosylated thyroid stimulating hormone receptor (TSHR) from porcine tissues as well as recombinant human TSHR. MA3-218 has been successfully used in Western blot, immunofluorescence, and ELISA procedures. By Western blot, this antibody detects a 50 kDa and a 63 kDa protein representing unglycosylated and glycosylated TSHR respectively, in transfected Sf9 cell extract. By ELISA MA3-218 has been used in TSH competitive inhibition studies. The MA3-218 antigen is purified extracellular domain of recombinant human thyrotropin receptor. This antibody recognizes an epitope between amino acid residues 277-296 of human TSHR.

TSH Receptor gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TSH Receptor
Applications ELISA, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 49
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.05% sodium azide
Gene TSHR
Gene Accession No. P16473, Q8SPP9
Gene Alias AI481368; CHNG1; hTSHR-I; hypothroid; hyt; LGR3; MGC141920; pet; seven transmembrane helix receptor; thyroid stimulating hormone receptor; thyroid stimulating hormone receptor, isoform 2; thyroid-stimulating hormone receptor; thyroid-stimulating hormone receptor variant; thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; TSHR; TSH-R; TSHR; seven transmembrane domain G protein-coupled receptor; TSHRA
Gene Symbols TSHR
Host Species Mouse
Immunogen Purified extracellular domain of recombinant human thyrotropin receptor.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 397560, 7253
Target Species Human, Pig
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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