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Invitrogen™ TTC30A Polyclonal Antibody
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Catalog No. PIPA521835
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100 μL
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PIPA521835 100 μL
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Catalog No. PIPA521835 Supplier Invitrogen™ Supplier No. PA521835
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, HepG2, Molt-4. Predicted reactivity: Rat (90%), Xenopus laevis (88%), Chicken (85%), Bovine (93%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The TTC30A gene encodes for the Tetratricopeptide Repeat Domain 30A, which is part of the intraflagellar transport (IFT) complex B, critical for ciliary function. TTC30A and its paralog TTC30B are involved in the stability and functioning of the IFT complex. These proteins play a redundant role in maintaining cilia integrity, necessary for proper cellular signaling and homeostasis. Disruption of TTC30A, through CRISPR/Cas9 gene editing, has shown to impair ciliogenesis, leading to developmental defects such as limb malformations and polycystic kidney disease due to altered tubulin acetylation and ciliary transport. This highlights the importance of TTC30A in cellular and developmental processes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen TTC30A
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene TTC30A
Gene Accession No. Q86WT1
Gene Alias IFT70A; tetratricopeptide repeat domain 30A; tetratricopeptide repeat domain 30B; tetratricopeptide repeat protein 30A; TPR repeat protein 30A; TTC30A
Gene Symbols TTC30A
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human TTC30A. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 92104
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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