Invitrogen™ TTYH2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534395

Catalog No. PIPA534395

Description

A suggested positive control is human kidney tissue lysate. PA5-34395 can be used with blocking peptide PEP-1437.

TTYH2 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions. TTYH2 is a Ca2+-activated large conductance chloride (Cl-) channel and may play a role in kidney tumorigenesis. It is also upregulated in colon carcinoma and is thought to play a role in cell proliferation and call aggregation, suggesting that TTYH2 may play a role in regulating both proliferation and metastatic potentials of colorectal cancer. The ubiquitin-protein ligase Nedd4-2 binds to and ubiquitinates TTYH2, thereby regulating its cell surface expression and total cellular levels.

Specifications

• Antigen: TTYH2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TTYH2
• Gene Alias: 1110001A03Rik; C17orf29; hTTY2; mTTY2; Protein tweety homolog 2; RGD1562969; TTYH2; tweety family member 2; tweety homolog 2; tweety homolog 2 (Drosophila)
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 117160, 287803, 94015
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q3TH73, Q9BSA4
• Gene Symbols: TTYH2
• Immunogen: A 14 amino acid synthetic peptide near the amino terminus of human TTYH2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG