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Tocris Bioscience™ Tubastatin A hydrochloride

Catalog No. 627010
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Catalog No. Quantity
62-701-0 10 mg
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Catalog No. 62-701-0 Supplier Tocris Bioscience™ Supplier No. 6270/10
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Description

Potent HDAC6 inhibitor

Tubastatin A hydrochloride is a potent HDAC6 inhibitor (IC50 = 0.015 μM). Exhibits some selectively for HDAC6 over HDAC8 and 1 (IC50 values are 0.854 and 16.4 μM, respectively). Induces elevated levels of α-tubulin and protects against glutathione-induced oxidative stress in primary neuronal cell culture. Reverses the axonal loss in peripheral neurons in a mouse model of Charcot-Marie-Tooth disease.

Specifications

Chemical Name or Material N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride
CAS 1310693-92-5
Assay Percent Range >98%
Quantity 10 mg
Molecular Formula C20H21N3O2.HCl
Formula Weight Observed MW: 371.86
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