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  5. Tocris Bioscience™ Tucatinib

Tocris Bioscience™ Tucatinib
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Catalog No. 764010
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective ErbB2 inhibitor

Tucatinib is a potent and selective ErbB-2 (also called HER2) kinase inhibitor (IC50 = 7 nM). It exhibits >50-fold selectivity for ErbB-2 over EGFR. In vitro, Tucatinib inhibits ErbB-2 signaling activity and cell proliferation in ErbB-2-amplified breast cancer cell lines (BT-474). In vivo, Tucatinib (25-100 mg/kg) reduces tumor volume in breast and gastric xenograft mouse models.This compound is orally bioavailable.

Specifications

Chemical Name or Material N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4 ]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine
CAS 937263-43-9
Quantity 10 mg
Target EGF Receptor Inhibitors
Molecular Formula C26H24N8O2
Purity 0.98
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