Invitrogen™ TWIST1 Recombinant Rabbit Monoclonal Antibody (BLR156J)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA544497

Catalog No. PIMA544497

Description

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

TWIST1 acts as a transcriptional regulator. It inhibits myogensis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.

Specifications

• Antigen: TWIST1
• Classification: Recombinant Monoclonal
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 6.8-7.4
• Gene Accession No.: Q15672
• Gene Symbols: TWIST1
• Immunogen: Peptide representing a region between residue 1 and 50 of Human Twist-related protein 1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: BLR156J
• Conjugate: Unconjugated
• Gene: TWIST1
• Gene Alias: AA960487; ACS3; B-HLH DNA binding protein; bHLHa38; BPES2; BPES3; charlie chaplin; class A basic helix-loop-helix protein 38; CRS; CRS1; CSO; H-twist; M-twist; p ACS3; Pde; pdt; Pluridigite; polydactyly EMS; SCS; Ska>m10Jus>; Ska>sup>m10Jus>/sup>; Ska10; Twist; twist basic helix-loop-helix transcription factor 1; twist family bHLH transcription factor 1; twist gene homolog 1; twist homolog 1; TWIST homolog of drosophila; Twist1; twist-related protein 1
• Host Species: Rabbit
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 7291
• Content And Storage: 4°C
• Form: Liquid