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TWIST1 and TWIST2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501984731
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50-198-4731 100 μL
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Catalog No. 50-198-4731 Supplier Bioss Supplier No. BS2441R
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Description

Rabbit Polyclonal Antibody

Twist1/Twist2 encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. Twist1/Twist2 is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism.

Specifications

Antigen TWIST1 and TWIST2
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene TWIST2
Gene Accession No. Q15672, Q8WVJ9
Gene Alias AA960487; ACS3; AMS; BBRSAY; B-HLH DNA binding protein; BHLHA38; BHLHA39; BPES2; BPES3; charlie chaplin; Class A basic helix-loop-helix protein 38; Class A basic helix-loop-helix protein 39; CRS; CRS1; CSO; dermis expressed 1; Dermis-expressed protein 1; DERMO1; Dermo-1; dermo-1 protein; FFDD3; H-twist; MGC117334; M-twist; Pde; pdt; Pluridigite; polydactyly EMS; SCS; SETLSS; Ska; Skam10Jus; Ska10; Twist; twist basic helix-loop-helix transcription factor 1; twist basic helix-loop-helix transcription factor 2; twist family bHLH transcription factor 1; twist family bHLH transcription factor 2; twist gene homolog 1; twist homolog 1; twist homolog 2; TWIST homolog of drosophila; Twist1; Twist2; twist-related bHLH protein Dermo1; Twist-related protein 1; Twist-related protein 2
Gene Symbols TWIST1, TWIST2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human TWIST1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117581, 7291
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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