Invitrogen™ Tyrosine Hydroxylase Monoclonal Antibody (TH-16)

Catalog No.	Quantity
PIMA532984	100 μg

Catalog No. PIMA532984 Supplier Invitrogen™ Supplier No. MA532984

Description

Mouse Monoclonal Antibody

Reconstitute with 1 mL of PBS buffer to yield a concentration of 100 μg/mL. Positive Control - WB: rat brain tissue, mouse brain tissue, human U-87MG cell. IHC: rat brain tissue. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

Specifications

• Antigen: Tyrosine Hydroxylase
• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: TH-16
• Concentration: 100 μg/mL
• Conjugate: Unconjugated
• Formulation: Ascites, 1.2% sodium acetate with 2mg BSA and 0.01mg sodium azide
• Gene: TH
• Gene Accession No.: P04177, P07101, P24529
• Gene Alias: dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase
• Gene Symbols: TH
• Host Species: Mouse
• Immunogen: Rat tyrosine hydroxylase (TH).
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100009362, 21823, 25085, 7054
• Target Species: Human, Mouse, Rat, Rabbit
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1