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Invitrogen™ Tyrosine Hydroxylase Polyclonal Antibody

Catalog No. PA14679
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100 μL
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PA14679 100 μL
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Catalog No. PA14679 Supplier Invitrogen™ Supplier No. PA14679
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Description

Sheep Polyclonal Antibody

This antibody is specific for the ~60 kDa Tyrosine Hydroxylase in Western blots of rat brain extracts.

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Tyrosine Hydroxylase
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.15 mg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100 μg/mL BSA, 0.15M NaCl, 50% glycerol and no preservative; pH 7.5
Gene TH
Gene Accession No. P04177, P07101, P24529
Gene Alias dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase
Gene Symbols TH
Host Species Sheep
Immunogen SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21823, 25085, 7054
Target Species Human, Mouse, Rat, Multi-species
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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