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  6. Invitrogen™ Tyrosine Hydroxylase Recombinant Rabbit Monoclonal Antibody (BLR155J)

Invitrogen™ Tyrosine Hydroxylase Recombinant Rabbit Monoclonal Antibody (BLR155J)
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Catalog No. p-200122080
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Quantity:
10 μL
100 μL
Catalog No. Quantity
PIMA544495 100 μL
PIMA544496 10 μL
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Catalog No. PIMA544495

Supplier: Invitrogen™ MA544495

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Description

Rabbit Recombinant Monoclonal Antibody

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Tyrosine Hydroxylase
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone BLR155J
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 6.8-7.4
Gene TH
Gene Accession No. P07101
Gene Alias dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase
Gene Symbols TH
Host Species Rabbit
Immunogen Peptide representing a region between residue 450 and 500 of Human Tyrosine hydroxylase.
Purification Method purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7054
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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