Tyrphostin A23, 99%, Thermo Scientific Chemicals

Description

Potent inhibitor of EGF receptor kinase activity

Tyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.

Solubility
Soluble in DMSO, ethanol, or DMF

Notes
Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents, acids, heat.

Specifications

Chemical Identifiers

• CAS: 118409-57-7
• Molecular Formula: C10H6N2O2
• Molecular Weight (g/mol): 186.17
• MDL Number: MFCD00133899
• InChI Key: VTJXFTPMFYAJJU-UHFFFAOYSA-N
• Synonym: tyrphostin 23, tyrphostin a23, 3,4-dihydroxybenzylidene malononitrile, tyrphostin ag18, tyrphostin rg50810, unii-rv0gcd31oj, 2-3,4-dihydroxyphenyl methylidene propanedinitrile, 2-3,4-dihydroxybenzylidene malononitrile, alpha-cyano-3,4-dihydroxy cinnamonitrile, propanedinitrile,2-3,4-dihydroxyphenyl methylene
• PubChem CID: 2052
• IUPAC Name: 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile
• SMILES: C1=CC(=C(C=C1C=C(C#N)C#N)O)O

• Color: Brown to Yellow
• Quantity: 25 mg
• Solubility Information: Soluble in DMSO, ethanol, or DMF
• Formula Weight: 186.17
• Percent Purity: 99%
• Physical Form: Powder
• Chemical Name or Material: Tyrphostin A23

Safety and Handling

TSCA	No
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only