Thermo Scientific Chemicals U0126, 99+%

Catalog No.	Quantity
AAJ61246MC	100 mg
AAJ61246MB	25 mg
AAJ61246EXH	300 mg

Catalog No. AAJ61246MC Supplier Thermo Scientific Chemicals Supplier No. J61246MC

Description

Selective inhibitor of mitogen-activated protein kinases MEK-1 and MEK-2 | CAS: 109511-58-2 | C18H16N6S2, C₁₈H₁₆N₆S₂ | 380.49 g/mol

U0126, is used as a selective MAP Kinase Kinase (MKK, MEK) inhibitor. U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Specifications

Chemical Identifiers

• CAS: 109511-58-2
• Molecular Formula: C₁₈H₁₆N₆S₂, C18H16N6S2
• Synonym: 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene

• Quantity: 100 mg
• Description: White
• Content And Storage: -30°C to -10°C
• For Use With (Application): Selective inhibitor of mitogen-activated protein kinases MEK-1 and MEK-2
• Formula Weight: 380.49g/mol
• Solubility: Soluble in DMSO; Poorly soluble in ethanol and water
• Product Type: Signal Transduction Reagent
• Form: Powder
• InChI Key: DVEXZJFMOKTQEZ-JYFOCSDGSA-N
• SMILES: N\C(SC1=CC=CC=C1N)=C(\C#N)/C(/C#N)=C(\N)SC1=CC=CC=C1N
• IUPAC Name: (2Z,3Z)-bis({amino[(2-aminophenyl)sulfanyl]methylidene})butanedinitrile
• Molecular Weight (g/mol): 380.49
• Assay: ≥99%

Safety and Handling

Recommended Storage

Store at -20°C

SDS

RUO – Research Use Only