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ATCC U937-DC-SIGN; Histiocytic Lymphoma; Human (Homo sapiens)
Supplier: ATCC CRL3253
U937-DC-SIGN was developed by transducing lymphocyte U-937 cells with the gene for human DC SIGN protein (Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin), a known attachment factor for Dengue viruses. The cloning vector used was pcDNA3 which contains SV-40 and CMV promoter regions. The U cell line that was established in 2008 from the stable transfection of U-937 cells (ATCC No. CRL-1593.2 isolated from a pleural effusion of a 37-year-old, white male patient with histiocytic lymphoma. This cell line was deposited by A. Desilva.
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