Invitrogen™ Ub-K63 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120617

Catalog No. PIPA5120617

Description

Positive test controls include: HeLa, HeLa+MG132, NIH/3T3, C6, Mouse brain, Rat brain.

Ubiquitin is a conserved 76 amino acid polypeptide and can affect proteasomal degradation of the protein it is bound to, or mediate interactions with other proteins related to post-translational modifications. The degradation of cellular regulatory proteins by the Uubiquitin pathway is important as it controls the cellular growth and proliferation. Ubiquitin-dependent proteolysis occurs after a covalent attachment of the peptide to a lysine residue of a protein, which involves three enzymatic reactions: E1, E2 and E3. The first reaction involves ubiquitin-activating enzyme. The third reaction uses enzyme ubiquitin ligase (E3) to transfer the activated ubiquitin from E2 to a lysine residue on a protein, or directly transfers the ubiquitin from E2 to the substrate.

Specifications

• Antigen: Ub-K63
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: UBB
• Gene Alias: 0610006J14Rik; 2700054O04Rik; 40S ribosomal protein S27a; 60S ribosomal protein L40; AI194771; AL033289; CEP52; CEP80; D8Ertd21e; epididymis luminal protein 112; epididymis secretory protein Li 50; Gm1863; HEL112; HEL-S-50; HMG20; HUBCEP52; L40; Large ribosomal subunit protein eL40; LOC100912032; polyubiquitin B; polyubiquitin C; polyubiquitin-B; Polyubiquitin-C; ribosomal protein S27A; RPL40; Rps27a; S27A; Small ribosomal subunit protein eS31; TI-225; Uba52; UBA80; Ubb; Ubb2; UBC; UBCEP1; UBCEP2; UBCEP80; Ubiquitin; Ubiquitin A-52 residue ribosomal protein fusion product 1; ubiquitin and ribosomal protein S27a; ubiquitin B; ubiquitin C; ubiquitin carboxyl extension protein 52; ubiquitin carboxyl extension protein 80; ubiquitin/60S ribosomal fusion protein; Ubiquitin-40S ribosomal protein S27a; ubiquitin-40S ribosomal protein S27a-like; ubiquitin-52 amino acid fusion protein; ubiquitin-60S ribosomal protein L40; ubiquitin-CEP52; ubiquitin-CEP80; Ubiquitin-related; Ubiquitin-related 1; Ubiquitin-related 2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100912032, 192255, 22186, 22187, 22190, 50522, 6233, 64156, 7311, 7314, 7316, 78294
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Dot Blot, ELISA
• Concentration: 0.29 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: P0CG47, P0CG48, P0CG49, P0CG50, P0CG51, P62979, P62982, P62983, P62984, P62986, P62987, Q63429
• Gene Symbols: RPS27A, UBA52, UBB, UBC
• Immunogen: A synthetic peptide corresponding to a sequence containing polyubiquitinated protein (K63 linkage).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG