UBASH3A Monoclonal Antibody (OTI5B4), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-2680	100 μL

Catalog No. 50-168-2680 Supplier OriGene Supplier No. TA809272

Description

Mouse Monoclonal Antibody

TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), STS-2 or CLIP4, is a 661 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one SH3 domain and one UBA domain. Expressed at high levels in thymus, bone marrow, spleen and peripheral blood leukocytes, TULA exists as either a homodimer or a homo-oligomer that interferes with the degradation of receptor-type tyrosine kinases and promotes the accumulation of activated receptors on the cell surface. Additionally, TULA is part of an EGFR- and Cbl-containing complex that interacts with ubiquitinated proteins. The gene encoding TULA, which maps to human chromosome 21, may be involved in the pathogenesis of type I diabetes. Multiple isoforms of TULA are produced due to alternative splicing events.

Specifications

• Antigen: UBASH3A
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI5B4
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: UBASH3A
• Gene Accession No.: P57075
• Gene Alias: CLIP4, STS-2, TULA, TULA-1
• Gene Symbols: UBASH3A
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 288-549 of human UBASH3A produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 53347
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b