UBASH3A Monoclonal Antibody (OTI5F10), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA809238

Catalog No. 50-168-2656

Description

TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), STS-2 or CLIP4, is a 661 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one SH3 domain and one UBA domain. Expressed at high levels in thymus, bone marrow, spleen and peripheral blood leukocytes, TULA exists as either a homodimer or a homo-oligomer that interferes with the degradation of receptor-type tyrosine kinases and promotes the accumulation of activated receptors on the cell surface. Additionally, TULA is part of an EGFR- and Cbl-containing complex that interacts with ubiquitinated proteins. The gene encoding TULA, which maps to human chromosome 21, may be involved in the pathogenesis of type I diabetes. Multiple isoforms of TULA are produced due to alternative splicing events.

Specifications

• Antigen: UBASH3A
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P57075
• Gene Symbols: UBASH3A
• Immunogen: Human recombit protein fragment corresponding to amino acids 288-549 of human UBASH3A produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI5F10
• Conjugate: Unconjugated
• Gene: UBASH3A
• Gene Alias: CLIP4, STS-2, TULA, TULA-1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 53347
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid