Invitrogen™ UBE3B Monoclonal Antibody (OTI3F10)

Catalog No.	Quantity
PIMA526807	100 μL

Catalog No. PIMA526807 Supplier Invitrogen™ Supplier No. MA526807

Description

Mouse Monoclonal Antibody

UBE3B Monoclonal Antibody for IHC (P)

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Specifications

• Antigen: UBE3B
• Applications: Immunohistochemistry (Paraffin)
• Classification: Monoclonal
• Clone: OTI3F10
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: UBE3B
• Gene Accession No.: Q7Z3V4
• Gene Alias: BPIDS; HECT-type ubiquitin transferase E3B; KOS; UBE3B; UBE3B_v2; ubiquitin protein ligase E3B; ubiquitin-protein ligase E3B
• Gene Symbols: UBE3B
• Host Species: Mouse
• Immunogen: Human recombinant protein fragment corresponding to amino acids 768-1068 of UBE3B produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 89910
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a