Invitrogen™ Ubiquilin 1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA1759

Catalog No. PA1759

Description

PA1-759 detects ubiquilin from hamster cells. PA1-759 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~63 kDa protein representing ubiquilin from CHO cell extract. PA1-759 immunizing peptide corresponds to amino acids residues 2-18 from mouse ubiquilin.

PLIC1 is an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease.

Specifications

• Antigen: Ubiquilin 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ubqln1
• Gene Alias: 1110046H03Rik; 1810030E05Rik; AU019746; C77538; D13Ertd372e; Da41; Dsk2; hPLIC-1; I79_020705; Plic1; PLIC-1; Protein linking IAP with cytoskeleton 1; testicular tissue protein Li 219; ubiquilin 1; ubiquilin-1; UBQLN1; UBQN; XDRP1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100764107, 29979, 56085
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: Q8R317, Q9UMX0
• Gene Symbols: Ubqln1
• Immunogen: Synthetic Peptide: A(2) E S A E S G G P P G A Q D S A A(18).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Hamster
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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