Invitrogen™ UBR2 Monoclonal Antibody (2G10)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA549290

Catalog No. PIMA549290

Description

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human HEK293 whole cell, human Jurkat whole cell, human K562 whole cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

The mammalian NUMB homolog plays a role in the determination of cell fate during development and binds with a variety of proteins, including Eps15, LNX1 and Notch 1. NumbL (NUMB-like protein), also known as Numb-R, NBL, CAG3A, CTG3a, NUMBLIKE or TNRC23, is a 609 amino acid cytoplasmic protein that, like NUMB, is thought to play a role in cell fate. Expressed at high levels in developing brain tissue, NumbL contains one PID (phosphotyrosine interaction domain) and plays an important role in neuronal differentiation, possibly associating with Eps15 and Notch 1. In mice, deletion of the NumbL gene is associated with early embryonic death, suggesting an essential role for NumbL in early development.

Specifications

• Antigen: UBR2
• Classification: Monoclonal
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and no preservative
• Gene Accession No.: Q8IWV8
• Gene Symbols: UBR2
• Immunogen: E.coli-derived human UBR2 recombinant protein (Position: Q10-A664).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Western Blot
• Clone: 2G10
• Conjugate: Unconjugated
• Gene: UBR2
• Gene Alias: 9930021A08Rik; AI462103; AW540746; bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3; E130209G04Rik; E3 ubiquitin-protein ligase UBR2; Kiaa0349; mKIAA0349; N-recognin-2; RING-type E3 ubiquitin transferase UBR2; si:ch211-239i4.2; ubiquitin ligase E3 alpha-II; ubiquitin protein ligase E3 component n-recognin 2; ubiquitin-protein ligase E3-alpha-2; Ubiquitin-protein ligase E3-alpha-II; Ubr2
• Host Species: Mouse
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23304
• Content And Storage: -20°C
• Form: Lyophilized