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Invitrogen™ UCN3 Monoclonal Antibody (C9), Invitrogen™

Catalog No. p-7240882
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100 μL
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PIMA543553 20 μL
PIMA543552 100 μL
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Catalog No. PIMA543553 Supplier Invitrogen™ Supplier No. MA543553
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Description

Mouse Monoclonal Antibody

Urocortin 3 (UCN3) is a member of the corticotropin-releasing factor (CRF) family, encoded by the UCN3 gene, and is primarily involved in stress response and energy balance regulation. UCN3 is predominantly expressed in the hypothalamus and certain peripheral tissues, such as pancreatic islets, where it plays significant roles in modulating anxiety-related behaviors and metabolism. This neuropeptide functions by binding to CRF2 receptors, exerting effects on glucose metabolism and insulin secretion. UCN3 has been implicated in protecting the heart from ischemic damage and modulating the cardiovascular system's response to stress, highlighting its potential in treating cardiac disorders. Additionally, it influences nutrient partitioning and energy homeostasis, with expression levels affected by nutritional status. Research indicates that UCN3 deficiency may lead to impaired glucose tolerance and altered energy expenditure, demonstrating its importance in metabolic health. Furthermore, UCN3 has been associated with the regulation of neuroendocrine signaling pathways, providing insights into therapeutic strategies for metabolic and stress-related disorders.
TRUSTED_SUSTAINABILITY

Specifications

Antigen UCN3
Applications Western Blot
Classification Monoclonal
Clone C9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene UCN3
Gene Accession No. Q969E3
Gene Alias prepro-urocortin 3; RGD1562213; SCP; SPC; Stresscopin; ucn III; Ucn3; UCNIII; urocortin 3; urocortin 3 (stresscopin); Urocortin II; Urocortin III; Urocortin-3
Gene Symbols UCN3
Host Species Mouse
Immunogen Leu22-Lys161 (Accession Q969E3), with N-terminal His Tag.
Purification Method Protein A/G
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114131
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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