ULBP1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-1737	150 μL

Catalog No. 50-173-1737 Supplier Proteintech Group Inc Supplier No. 177151AP150UL

Description

Rabbit Polyclonal Antibody

ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Specifications

• Antigen: ULBP1
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.13 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: ULBP1
• Gene Accession No.: Q9BZM6
• Gene Alias: ALCAN beta, N2DL 1, N2DL1, NKG2D ligand 1, NKG2DL1, RAET1I, UL16 binding protein 1, ULBP1
• Gene Symbols: Ulbp1
• Host Species: Rabbit
• Immunogen: ULBP1 Fusion Protein Ag12079
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 77777, 80329
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG